A high-performance fluidic cartridge specifically optimized for large-scale injection molding was engineered, moving the design from a prototype toward a mass-producible product. The heart of the solution was a series of specialized manifold transitions that gradually step down the fluid volume from the macro-input to the micro-channels. By refining the internal geometry, we were able to maintain a continuous, laminar flow that minimizes the amount of sample trapped in the system. This ensures that even small concentrations of biomarkers reach the sensors efficiently. The final design doesn’t just work on a functional level; it also respects the strict draft angles and wall-thickness requirements necessary for high-throughput manufacturing, ensuring a low cost-per-unit without sacrificing the precision required for high-accuracy analysis.